Title :

Tailoring Cell Microenvironment Cues to Guide Mesenchymal Stem Cell Chondrogenesis for Engineering Cartilage Tissue

Speaker :

Dr. Liming BIAN

Polymeric Biomaterials Laboratory, Department of Bioengineering

University of Pennsylvania, USA

Venue :

Room 215, William M. W. Mong Engineering Building, CUHK

Date :

Feb 21, 2012, Tuesday
2:00 PM - 3:00 PM

Abstract :

When endogenous repair fails, as is often the case with musculoskeletal tissues (like the articular cartilage, knee meniscus, bone, intervertebral disc etc.), novel strategies and enabling technologies must be developed to enhance tissue regeneration. Since the late 1990s, tissue engineering has been developing at a significant pace towards clinically relevant technology to promote tissue regeneration. Meanwhile, in recent years, mesenchymal stem cells (MSCs) have been evolving with increasing popularity as a clinically relevant cell source within the rapidly expanding field of tissue engineering. Furthermore basic science studies have shown that the survival, maintenance and differentiation of stem cells are tightly regulated by mechanical, biochemical, intercellular and neural signals from their local microenvironment. This seminar talk focuses on the effects of mechanical and biochemical cues (soluble factors and insoluble substrate materials) on the chondrogenic differentiation of MSCs for cartilage repair. Our findings demonstrate that carefully designed mechanical conditioning regimen, functionalized scaffold materials and controlled delivery of chemical factors are crucial to the development of tissue engineered cartilage using MSCs. These findings provide important insights into clinical translation of stem cell therapy for cartilage repair.

Biography :

Dr. Liming Bian has been a postdoctoral researcher working for Dr. Jason A. Burdick at the Polymeric Biomaterial Laboratory in the Department of Bioengineering, the University of Pennsylvania since 2009. After receiving his B.Eng and M.Sc degree from the National University of Singapore in 2002 and 2004, respectively, Dr. Bian completed his Ph.D. study in Biomedical Engineering under the advisory of Dr. Clark T. Hung and Dr. Gerard A. Ateshian at Columbia University in 2009. His research is focused on stem cell tissue engineering for repairing soft musculoskeletal tissues. Dr. Bian is also interested in the development of biomaterial platforms to investigate the role of cell microenvironment factors including mechanical, chemical and cell-matrix interactions in stem cell differentiation.

Dr. Bian`s work has been published in peer-reviewed journals including Tissue Engineering, Biomaterials, the Journal of American Sports Medicine, Osteoarthritis and Cartilage and the Journal of Biomechanics. Dr. Bian is an affiliated member of the Orthopedic Research Society, American Chemical Society and Society for Biomaterials. Dr. Bian also served as an active reviewer for Tissue Engineering, the Journal of Biomedical Materials Research and the Journal of Biomechanical Engineering.

    **************************************** ALL ARE WELCOME ****************************************

Enquiries: Ms. Winnie Wong, Department of Mechanical and Automation Engineering, CUHK at 3943 8337. *MAE Series (2011-12) is contained in the World-Wide Web home page at http://www3.mae.cuhk.edu.hk/maeseminars.php#mae.