Title :

Convergence of Nanophotonics and Microfluidics for Nanomedicine in Theranostics

Speaker :

Dr. Megan Yi-Ping Ho

Postdoctoral Research Associate, Department of Biomedical Engineering

Duke University, USA

Venue :

Room 215, William M. W. Mong Engineering Building, CUHK

Date :

Jan 18, 2012, Wednesday
2:00 PM - 3:00 PM

Abstract :

Translating genome-based knowledge into clinical health benefits is one of the most critical elements for the future nanomedicine. As biology becomes more quantitative, our understanding of the genetic contribution to disease is becoming more refined. However, subpopulations within mixtures of molecules under both equilibrium and non-equilibrium conditions complicate the dissection of complex dynamics of biological processes. To this end, we developed a single particle quantum dot (QD) based biosensing platform, which integrates nanophotonics with microfluidics, for both diagnostics and therapeutics. Single particle biosensing renders better understanding of biophysical properties and dynamics at the single molecules/complex level, allowing heterogeneity in the populations to be directly observed. In this talk, we will evaluate this platform specifically on three aspects: (1) identification of multiple disease-related genes for medical diagnostics, (2) study of delivery barriers for nucleic acids based therapeutics, and (3) characterization and optimization of gene-carrying nanocomplexes. The single particle QD platform, serving as a generic biosensing scheme to investigate a variety of biological entities and their interactions, is expected to advance modern biology by elucidating various biological interactions and to facilitate genetic medicine by contributing fundamentally to therapeutic design.

Biography :

Dr. Megan Yi-Ping Ho received her B.S. and M.S. in Power Mechanical Engineering from National Tsing-Hua University, Taiwan and Ph.D. in Mechanical Engineering from Johns Hopkins University, respectively. Her research focuses on integrating nanophotonics, novel molecular constructs and microfluidics for detecting nucleic acids in the context of disease diagnostics and gene therapy. She has received more than 10 academic honors and awards, published 19 peer-reviewed international journals, more than 30 conference abstracts and filed 3 patents.

    **************************************** ALL ARE WELCOME ****************************************

Enquiries: Ms. Winnie Wong, Department of Mechanical and Automation Engineering, CUHK at 3943 8337. *MAE Series (2011-12) is contained in the World-Wide Web home page at http://www3.mae.cuhk.edu.hk/maeseminars.php#mae.