Associate Professor
B.S., National Tsing Hua University, 1999
S.M., Massachusetts Institute of Technology, 2003
Ph.D., Massachusetts Institute of Technology, 2007
Member of ASPE
Member of ASME
Mechanical and Automation Engineering
Room 307, William M.W. Mong Engineering Building
Chinese University of Hong Kong, Shatin, N.T.
Hong Kong SAR, China
(852) 3943 4136
(852) 2603 6002
Multiscale Precision Instrumentation Laboratory


Prof. Shih-Chi Chen received his B.S. degree in Mechanical Engineering from the National Tsing Hua University, Taiwan, in 1999. He received his S.M. and Ph.D. degrees in Mechanical Engineering from the Massachusetts Institute of Technology, Cambridge, in 2003 and 2007, respectively. Following his graduate work, he entered a post-doctoral fellowship in the Wellman Center for Photomedicine, Harvard Medical School, where his research focused on biomedical optics and endomicroscopy. From 2009 to 2011, he was a Senior Scientist at Nano Terra, Inc., a start-up company founded by Prof. George Whitesides at Harvard University, to develop precision instruments for nanofabrication processes. In 2011, he joined the Department of Mechanical and Automation Engineering at the Chinese University of Hong Kong (CUHK) as an Assistant Professor. His current research interests include ultrafast laser applications, biomedical optics, precision engineering, and nanomanufacturing. Prof. Chen is a member of the American Society for Precision Engineering (ASPE), ASME, SPIE, OSA, and IEEE. He is the recipient of a 2003 R&D 100 Award for the design of a microscale six-axis nanopositioner. In 2013, he received the Early Career Award from University Grants Committee of Hong Kong.


My research aims to generate the scientific knowledge required to design novel precision and optical instrumentations at various length scale for measuring, manipulating, visualizing, and manufacturing things at micrometer and nanometer scales. We use the principles of mechanical design, precision engineering, optics, chemistry, biology and manufacturing - in combination with invention - to create new models, tools, machines, and fabrications processes that accelerate discoveries in medicine and science. Towards this goal, we have developed the following research directions:

  • ultrafast laser applications
  • biomedical optics
  • precision engineering
  • nanomanufacturing

Teaching by Years


  • MAEG5404 Micromachining and Microelectromechanical Systems
  • MAEG3040 Mechanical Design
  • MAEG3030 Fluid Mechanics

  • MAEG5404 Micromachining and Microelectromechanical Systems
  • MAEG3040 Mechanical Design

  • ENGG5404 Micromachining and Microelectromechanical Systems
  • BMEG3210 Biofluids

  • BMEG3210 Biofluids
  • MAEG3090 Advanced Energy Technology
  • ENGG1100 Introduction to Engineering Design (Project Mentor)

  • MAEG3090 Advanced Energy Technology
  • BMEG3210 Biofluids

Honors & Awards

  • Early Career Award, University Grants Committee of Hong Kong (2013)
  • MGH-MIT Career Development Postdoctoral Fellowship in Translational Research (2007)
  • R&D 100 Award for One of 100 Best New Technical Products of the Year-HexFlexTM Nanomanipulator, shared with Mr. Gordon Anderson, and Dr. Martin Culpepper. (2003)
  • MIT Martin Fellow & Martin Fellowship, Martin Family Society of Fellows for Sustainability, MIT (2003)
  • Lee Fellowship, Department of Mechanical Engineering, MIT (2001)
  • Recipient of Academic Achievement Award (top 2% of class) from National Tsing Hua University (NTHU) for 7 times. (1996-1999)
  • Outstanding Engineering Student Prize, Chinese Institute of Engineers (1999)
  • Dr. Cho-Chien Chien Scholarship, Chinese Society of Mechanical Engineers (1999)
  • Mr. Tzu-His Lin Scholarship, Ministry of Education, Taiwan (1999)
  • The Scholarship from the United World Chinese Commercial Bank Culture and Charity Foundation (1999)
  • Research Creativity Award, National Science Council of Taiwan (1998)
  • NTHU Tai Ta Electronics Scholarship (1998)
  • Yu Kuo-Hua Scholarship, Yu Kuo-Hua Culture and Education Foundation (1998)
  • NTHU Yung Tuan Scholarship (1997)

Journal Papers (in the recent five years)

  • C. Li, J. Wang, and S. Chen, "Flexure-based Dynamic-Tunable Five-Axis Nanopositioner for Parallel Nanomanufacturing," Precision Engineering, Vol. 45, pp. 423-434, 2016.
  • J. Cheng, C. Gu, D. Zhang, D. Wang, and S. Chen, "Ultrafast Axial Scanning for Two-photon Microscopy via a Digital Micromirror Device and Binary Holography," Optics Letters, Vol. 41, No. 7, pp. 1451-54, 2016.
  • X. Zhou, D. Wang, J. Wang, and S. Chen, "Design and Control of a Flexure-Based Roll-to-roll Printing System," Precision Engineering, Vol. 45, pp. 332-341, 2016.
  • N. Luo, W. Dai, C. Li, Z. Zhou, L. Lu, C.C.Y. Poon, S. Chen, Y. Zhang, and N. Zhao, "Flexible Piezoresistive Sensor Patch Enabling Ultralow Power Cuffless Blood Pressure Measurement," Advanced Functional Materials, Vol. 26, No. 8, pp. 1178-87, 2016.
  • J. Chen, J. Cheng, D. Zhang and S. Chen, "Precision UV Imprinting System for Parallel Fabrication of Large-area Micro-lens Arrays on Nonplanar Surfaces," Precision Engineering, Vol. 4, pp. 70-74, 2016.
  • J. Cheng, C. Gu, D. Zhang, and S. Chen, "High-speed femtosecond laser beam shaping based on binary holography using a digital micromirror device," Optics Letters, Vol. 40, No. 21, pp. 4875-78, 2015.
  • J. Jiang, D. Zhang, C. Gu, S. Walker, Y. Ke, W. Yung, and S. Chen, "Fast 3-D Temporal Focusing Microscopy Using an Electrically-tunable-lens," Optics Express, Vol. 23, No. 19, pp. 24362-68, 2015.
  • F.Y. Lee, X. Zhou, X. Yang, W. Fang, S. Chen, "Design of a Tunable Resonant Micromirror," Sensors & Actuators: A. Physical, Vol. 234, pp. 72-81, 2015.
  • C. Gu, Y. Chang, D. Zhang, J. Cheng, and S. Chen, "Femtosecond Laser Pulse Shaping at Megahertz Rate via a Digital Micromirror Device," Optics Letters, Vol. 40, No. 17, pp. 4018-21, 2015.
  • J. Chen, C. Gu, H. Lin, and S. Chen, "Soft Mold-based Hot Embossing Process for Precision Imprinting of Optical Components on Nonplanar Surfaces," Optics Express, Vol.23, No. 16, pp. 20977-985, 2015.
  • C. Gu, D. Zhang, Y. Chang and S. Chen, "Digital Micromirror Device-based Ultrafast Pulse Shaping for Femtosecond Laser,"Optics Letters, Vol. 40, No. 12, pp. 2870-73, 2015.
  • S.M. Yang, W. Chen, D. Zhang, and S. Chen, "A Flow-Free Droplet-Based Device for High Throughput Polymorphic Crystallization," Lab on a Chip, Vol. 15, pp. 2680-87, 2015.
  • X. Zhou, H. Xu, N. Zhao, and S. Chen, "Flexure-based Roll-to-roll Platform: A Practical Solution for Realizing Large-area Microcontact Printing," Scientific Reports, Vol. 5, 10402, 2015.
  • S.M. Yang, H. Yao, D. Zhang, W.J. Li, H.F. Kung, and S. Chen, "Droplet-based Dielectrophoresis Platform for Polymeric Nanoparticle Separation and Improved Gene Delivery Efficiency," Microfluidics and Nanofluidics, Vol. 19, No. 1, pp. 235-43, 2015.
  • S. Chen, H. Choi, P. T.C. So, and M. L. Culpepper, "Thermomechanical Actuator-Based Three-axis Optical Scanner for High-Speed Two-photon Endomicroscope Imaging ," Journal of Microelectromechanical Systems, 2014, Vol. 23, No. 3, pp. 570-78.
  • H. Yao, S. Chen, Z. Shen, Y.C. Huang, X. Zhu, X.M. Wang, W. Jiang, Z.F. Wang, X.W. Bian, E.A. Ling, H.F. Kung, M.C. Lin, "Functional Characterization of a PEI-CyD-FA-coated Adenovirus as Delivery Vector for Gene Therapy," Current Medicinal Chemistry, Vol. 20, No. 20, pp. 2601-08(8), 2013.
  • L.H. Chau, W. Liang, F. Cheung, W.K. Liu, W.J. Li, S. Chen, G.B. Lee, "Self-Rotation of Cells in an Irrotational AC E-Field in an Opto-Electrokinetics Chip," PLoS ONE 8(1): e51577. doi:10.1371/journal.pone.0051577, 2013.
  • W.M. Fu, J.F. Zhang, H. Wang, Z.C. Xi, W.M. Wang, P. Zhuang, X. Zhu, S. Chen, T.M. Chan, K.S. Leung, G. Lu, H.X. Xu, H.F. Kung, "Heat Shock Protein 27 Mediates the Effect of 1,3,5-trihydroxy-13,13-dimethyl-2H-pyran [7,6-b] Xanthone on Mitochondrial Apoptosis in Hepatocellular Carcinoma," Journal of Proteomics, Vol. 75, Issue 15, pp. 4833-43, 2012.
  • W.M. Fu, J.F. Zhang, H. Wang, H.S. Tan, W.M. Wang, S. Chen, X. Zhu, T.M. Chan, C.M. Tse, K.S. Leung, G. Lu, H.X. Xu, H.K. Kung, "Apoptosis Induced by 1,3,6,7-Tetrahydroxyxanthone in Hepatocellular Carcinoma and Proteomic Analysis," Apoptosis, Vol. 17, No. 8,pp. 842-51, 2012.
  • S. Chen and M. L. Culpepper, "Design of Contoured Thermomechanical Actuators and Pulsing Actuation to Enhance Dynamic Performance," Journal of Microelectromechanical Systems, 2012, Vol. 21, Issue 2, pp. 340-49.
  • S. Chen and M. L. Culpepper, "Design of Contoured Microscale Thermomechanical Actuators," Journal of Microelectromechanical Systems, 2006, Vol. 15, Issue 5, pp. 1226-34.
  • S. Chen and M. L. Culpepper, "Design of a Six-axis Microscale Nano-positioner - µHexflex," Journal of Precision Eng. 2006, Vol. 30, Issue 3, pp. 314-24.